Recognizing deviations from normalcy for brain tumor segmentation

A framework is proposed for the segmentation of brain tumors from MRI. Instead of training on pathology, the proposed method trains exclusively on healthy tissue. The algorithm attempts to recognize deviations from normalcy in order to compute a fitness map over the image associated with the presence of pathology. The resulting fitness map may then be used by conventional image segmentation techniques for honing in on boundary delineation. Such an approach is applicable to structures that are too irregular, in both shape and texture, to permit construction of comprehensive training sets. The technique is an extension of EM segmentation that considers information on five layers: voxel intensities, neighborhood coherence, intra-structure properties, inter-structure relationships, and user input. Information flows between the layers via multi-level Markov random fields and Bayesian classification. A simple instantiation of the framework has been implemented to perform preliminary experiments on synthetic and MRI data.